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HPE ProLiant DL385 Gen10 Plus Server - System Overview


HPE DL385 Gen10 Plus side view

Designed to meet the needs of virtual desktop infrastructure, software-defined storage (SDS) and high-performance computing (HPC) workloads, the HPE ProLiant DL385 Gen10 Plus provides security and dense deployment for space-constrained environments. Outfitted with dual 1st or 2nd Generation AMD EPYC 7000 Series Processors, it supports PCIe 4.0 slots allowing for greater expansion of the system capabilities. Up to 8TB of memory can be installed on this system.


Dual 2nd Generation AMD EPYC 7000 Series Processors provide the necessary computational power for a number of diverse workloads. A maximum of 64x Physical Cores and 128x Virtual Threads, per processor, are supported on this system. AMD EPYC CPUs also support PCIe 4.0, which offers twice the throughput compared to PCIe 3.0.


The storage options on the HPE DL385 Gen10 Plus server vary. Configurations include 8x or 12x Large Form Factor SAS/SATA/SSD drive bays with an optional 4x LFF and 2x SFF bays in the back of the system. Another option features 8x or 24x SFF SAS/SATA/SSD drive bays with 4x optional rear drive bays. The last option is 16x SFF NVMe drive bays on the front of the system. The 8-bay LFF chassis cannot be upgraded to support 12x storage bays in the field.


With 32x DIMM slots evenly divided between the two CPU sockets. With 8x memory channels per CPU, there are 16x slots per socket with each channel supporting 1x or 2x memory modules. A fully configured HPE 385 Gen10 Plus supports up to 8TB of memory. To achieve this, 32x 256GB DDR4 Load Reduced DIMM modules are installed in each memory module slot. The maximum memory speed of 3200MT/s is limited by the processor and also memory configuration. 2 DIMMs per channel will drop the supported memory speeds to 2933MT/S.


HPE DL385 Gen10 Plus rear detail view

A maximum of 8x expansion slots are supported on this system depending on your choice of expansion card risers. The Primary Riser slots are controlled by Processor 1 and they include PCIe 4.0 technology with bus widths of x16 and x8. The Secondary Riser also has a similar layout with PCIe 4.0 technology and x16 or x8 bus widths.


Included in the system’s management suite is HPE’s proprietary software, integrated Lights Out (iLO) Standard, which does require a download. For additional capabilities, there’s iLO Advanced or iLO Advanced OneView, both of which can be downloaded but also require licensing. iLO is useful for out-of-band management of the system, generating alerts, allocating assets and monitoring the general health of the system.


The HPE ProLiant DL385 Gen10 Plus is a flexible 2U server ideal for virtual machine deployment and dense high-performance computing applications. Dual AMD EPYC processors deliver 8x to 64x Physical Cores and 16x to 128x Virtual Threads, plus support for PCIe 4.0 and up to 8TB of memory. A variety of storage options give this platform the ability to support a number of mission critical workloads.

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HPE ProLiant DL385 Gen10 Plus Server - Specifications

Processor - 2 sockets
  • 1st Generation AMD EPYC 7000 Series
  • 2nd Generation AMD EPYC 7000 Series
    Memory Capacity

  • 32 x DIMM slots
  • Up to 8TB HPE using LRDIMM with 256GB x modules
  • Memory Speed

  • When 2 x DIMMs are populated per channel, memory speed drops to 2933MT/S
Drive Bays
  • 8 or 12 x LFF SAS/SATA/SSD with 4 x LFF rear drive optional and and 2 x SFF rear drive optional
  • 8 or 24 x SFF SAS/SATA/SSD with 4 x SFF rear drive optional
  • 16 x SFF NVMe Front bay
I/O Ports

  • Optional, rear
  • Display Port

  • 1 x optional front display port via Universal Media Bay
  • VGA Port

  • 1 x Standard, rear for all chassis
  • Network Ports

  • None. Choice of OCP or stand up card
  • HPE iLO Remote Management Network Port

  • 1 Gb Dedicated
  • Front iLO Service Port

  • 1 x standard (Not available on 12 LFF chassis or when SID is ordered, note iLO dongle required, 880123-B21)
  • USB 3.1 Gen1

  • Up to 7 x total: 1 x front, 2 x rear, 2 x internal (secure), 2 x optional USB 3.0 front via Universal Media Bay, or standard on 8 LFF chassis
  • SID (Systems Insight Display)

  • Optional
    Form Factor

  • 2U
  • Weight

  • 33.25lb (15.1kg)
  • Product Dimensions

  • 3.44 x 17.54 x 29.5 in (8.73 x 44.54 x 74.9 cm)
On-Board Devices

  • No Chipset, System on Chip (SoC) Design
  • Storage Controller

  • HPE NS204i-p NVMe PCIe3 OS Boot Device
  • HW RAID 0, 1, 5, 10 support; 2G Cache
  • Network Controllers

  • Choice of optional OCP plus standup, depending on model

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Get a quote for HPE ProLiant DL385 Gen10 Plus Server

If you know what you want but can't find the exact configuration you're looking for, have one of our knowledgeable sales staff contact you. Give us a list of the components you would like to incorporate into the system, and the quantities, if more than one. We will get back to you immediately with an official quote.

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